• Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses 

      Tusco, Radu; Jacomin, Anne-Claire; Jain, Ashish; Penman, Bridget S.; Larsen, Kenneth Bowitz; Johansen, Terje; Nezis, Ioannis P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-02)
      Selective autophagy is a catabolic process with which cellular material is specifically targeted for degradation by lysosomes. The function of selective autophagic degradation of self-components in the regulation of innate immunity is still unclear. Here we show that Drosophila Kenny, the homolog of mammalian IKKγ, is a selective autophagy receptor that mediates the degradation of the IκB kinase ...